Deborah M Proctor Selected Research

Hyperplasia

1/2020	An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet.
1/2018	Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium.
12/2017	Comparison of Toxicity and Recovery in the Duodenum of B6C3F1 Mice Following Treatment with Intestinal Carcinogens Captan, Folpet, and Hexavalent Chromium.
8/2015	Duodenal crypt health following exposure to Cr(VI): Micronucleus scoring, γ-H2AX immunostaining, and synchrotron X-ray fluorescence microscopy.
1/2015	Synchrotron-based imaging of chromium and γ-H2AX immunostaining in the duodenum following repeated exposure to Cr(VI) in drinking water.
5/2014	A chronic oral reference dose for hexavalent chromium-induced intestinal cancer.
3/2013	Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans.
10/2012	Assessment of genotoxic potential of Cr(VI) in the mouse duodenum: an in silico comparison with mutagenic and nonmutagenic carcinogens across tissues.
1/2012	Assessment of Cr(VI)-induced cytotoxicity and genotoxicity using high content analysis.
9/2011	Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium.

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Deborah M Proctor Research Topics

Disease

33	Neoplasms (Cancer) 04/2024 - 05/2002
10	Hyperplasia 01/2020 - 09/2011
9	Carcinogenesis 05/2019 - 09/2011
5	Lung Neoplasms (Lung Cancer) 05/2019 - 05/2002
3	Intestinal Neoplasms (Intestinal Cancer) 01/2017 - 05/2014
2	AIDS-Related Complex (ARC) 04/2024 - 01/2023
2	Inflammation (Inflammations) 11/2014 - 01/2011
1	Anemia 03/2014
1	Iron Deficiencies 03/2014
1	Carcinoma (Carcinomatosis) 03/2013
1	Adenoma (Adenomas) 03/2013
1	Rectal Neoplasms (Rectal Cancer) 08/2010
1	Esophageal Neoplasms (Esophageal Cancer) 08/2010
1	Digestive System Neoplasms (Cancer of the Digestive System) 05/2002

Drug/Important Bio-Agent (IBA)

30	chromium hexavalent ionIBA 04/2024 - 05/2002
16	Drinking WaterIBA 01/2018 - 05/2002
6	CarcinogensIBA 12/2017 - 05/2002
3	ChromatesIBA 03/2016 - 08/2010
3	sodium bichromate (sodium dichromate)IBA 06/2013 - 01/2012
2	ManganeseIBA 04/2024 - 01/2023
2	IronIBA 01/2023 - 01/2012
2	folpet (Phaltan)IBA 01/2020 - 12/2017
2	CaptanIBA 01/2020 - 12/2017
2	MetalsIBA 01/2020 - 08/2016
2	ethyl acrylateIBA 07/2018 - 07/2018
2	Proteins (Proteins, Gene)FDA Link 01/2017 - 11/2014
2	DNA (Deoxyribonucleic Acid)IBA 01/2015 - 01/2011
1	ArsenicIBA 04/2024
1	CarbonIBA 01/2023
1	cobalt sulfateIBA 08/2016
1	CobaltIBA 08/2016
1	GATIBA 06/2013
1	Codon (Codons)IBA 06/2013
1	CytokinesIBA 01/2012